Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Joint Agency Name:
PI Name:
Qin, Yi-Xian
PI Phone:
631-632-1481
PI Email:
yi-xian.qin@sunysb.edu
Fax:
631-632-8577
PI Organization Type:
UNIVERSITY
Organization Name:
SUNY- The State University of New York
PI Address 1:
Department of Biomedical Engineering
PI Address 2:
100 Nicolls Rd., 350 Psychology A Building 3rd Floor
PI Web Page:
City: Stony Brook
State: NY
Zip Code: 11794-0002
Congressional District: 1
Comments:
Project Type:
GROUND
Solicitation:
NNJ07ZSA002N
Start Date:
11/01/2008
End Date:
10/31/2012
Fiscal Year:
2009
No. of Post Docs:
No. of PhD Degrees:
No. of PhD Candidates:
No. of Master' Degrees:
No. of Master's Candidates:
No. of Bachelor's Degrees:
No. of Bachelor's Candidates:
Monitoring Center:
NSBRI
Contact Monitor:
Contact Phone:
Contact Email:
Flight Program:
Flight Assignment:
Key Personnel Changes/Previous PI:
COI Name:
COI Institution:
Mirza, Naureen
The Research Foundation of the State University of New York
Gelato , Marie
The Research Foundation of the State University of New York
Rubin, Clinton
State University of New York
Grant/Contract No.:
NCC 9-58-SMST01603
Performance Goal No.:
Performance Goal Text:
Task Description:
Musculoskeletal complications, i.e., osteoporosis, induced by microgravity during extended space mission and age-related disorders represent a key health problem. Osteoporosis will diminish both the structure and strength of bone, each considered critical in defining the ability of the bone to resist fracture. Early diagnosis of such progressive bone loss would allow prompt treatment, and thus inherently reduce the risk of fracture. Bone mineral density (BMD) measurement is a well-accepted, standard assessment used for the diagnosis of osteopenia and osteoporosis, using dual-energy X-ray Absorptiometry (DXA) in the clinic. However, it is limited to a BMD index and insensitive to bone's physical properties. Advents in quantitative ultrasound (QUS) techniques can characterize both BMD and the material properties. Using a newly developed noninvasive Scanning Confocal Acoustic Diagnostic (SCAD) technology, strong correlations between SCAD determined data and bone's structural and strength parameters were observed. Ultrasound has also been shown therapeutic potentials to accelerate fracture healing. The objectives of this study are to develop a combined diagnostic and treatment ultrasound technology for early prediction of bone disorder and guided acceleration of fracture healing, using SCAD imaging and low-intensity pulse ultrasound. The technology will target to the critical skeletal sites, where may be significantly affected by disuse osteopenia and potentially at the risk of fracture, i.e., hip, long bone and wrist regions. We will evaluate bone¿s quality in clinical human subjects, and at the JSC/UTMB bedrest facility. Animal models and cadaver will be used for testing feasibility of identifying bone loss, fracture, and longitudinally treatment and monitoring. A noninvasive diagnostic and treatment technology using ultrasound will have significant potentials to prevent and treat bone fracture, and will address critical questions in the Bioastronautics Roadmap related to bone loss monitoring, prevention and recovery.
Research Impact/Earth Benefits:
A noninvasive diagnostic and treatment technology using ultrasound will have significant potentials to prevent and treat bone fracture.
Developed and operated by: NASA Research and Education Support Services