Renee N. Juhans
Headquarters, Washington, DC December 1, 1998
(Phone: 202/358-1712)

RELEASE: 98-217

NASA ANNOUNCES RESEARCH GRANTS IN MICROGRAVITY BIOTECHNOLOGY

NASA has selected 48 researchers to receive grants totaling approximately $33 million to conduct microgravity biotechnology research. Forty of the grants are to conduct ground-based research, while the remaining eight are flight definition efforts. Fourteen of these grants are for continuation of work currently being funded by NASA, but the majority (34) represent new research efforts.

Sponsored by NASA's Office of Life and Microgravity Science and Applications, this research allows investigators to take advantage of a low-gravity environment to improve understanding of fundamental physical and chemical processes associated with biotechnology. The research support by NASA under this announcement includes protein crystallization, cell science studies, and new technology development. This research may affect such important areas as structure-based drug design, tissue engineering, and biosensor development.

The investigators will have NASA's microgravity research facilities such as aircraft flying parabolic trajectories and sounding rockets at their disposal; the flight-definition investigators will work toward experiments on the International Space Station.

NASA received 165 proposals in response to its announcement in this research area. These proposals were peer-reviewed by scientific and technical experts from academia, government and industry. In addition, those proposals selected for flight definition were reviewed in terms of engineering feasibility by a team from NASA's Marshall Space Flight Center. Huntsville, AL.

A list of awardees (by state), their institutions, and research titles can be found below

 
Alabama
Dr. Daniel C. Carter
New Century Pharmaceuticals, Inc.
Huntsville, AL
"Protein Crystal Growth Facility-Based Microgravity Hardware:
Science and Applications"
 
Dr. Lawrence J. DeLucas
University of Alabama, Birmingham
Birmingham, AL
"Microgravity Studies of Medically Relevant Macromolecules"
 
Dr. Russell Judge
NASA Marhsall Space Flight Center
Huntsville, AL
"Macromolecule Nucleation and Growth Rate Dispersion Studies: A
Predictive Technique for Crystal Quality Improvement in
Microgravity"
 
Dr. Craig E. Kundrot
NASA Marshall Space Flight Center
Huntsville, AL
"Optimizing the Use of Microgravity to Improve the Diffraction
Quality of Problematic Biomacromolecular Crystals"
 
Dr. Robert J. Naumann
University of Alabama, Huntsville
Huntsville, AL
"Control of Transport in Protein Crystal Growth using Restrictive
Geometries"
 
Dr. Marc L. Pusey
NASA Marshall Space Flight Center
Huntsville, AL
"The Role of Specific Interactions in Protein Crystal Nucleation
and Growth Studied by Site-directed Mutagenesis"
 
Dr. Robert S. Snyder
New Century Pharmaceuticals
Huntsville, AL
"Electrophoretic Focusing"
 
Dr. Peter O. Vekilov
University of Alabama, Huntsville
Huntsville, AL
"Effects of Convective Transport of Solute and Impurities on
Defect-Causing Kinectics Instabilities in Protein Crystallization"
 
California
Dr. John A. Frangos
University of California, San Diego
La Jolla, CA
"Novel Strategy for Tridimensional In Vitro Bone Induction"
 
Dr. Frances Jurnak
University of California, Irvine
Irvine, CA
"Stabilization and Preservation of Crystals for X-ray Diffraction
Experiments"
 
Dr. James L. Lambert
NASA Jet Propulsion Laboratory
Pasadena, CA
"Development of a Non-Invasive Glucose Monitor"
 
Dr. Alexander J. Malkin
University of California, Irvine
Irvine, CA
"Growth Processes and Defect Structure of Macromolecular Crystals"
 
Professor Robert Sah
University of California, San Diego
La Jolla, CA
"Cartilage Tissue Engineering: Circumferential Seeding of
Chondrocytes Using Rotating Reactors"
 
Florida
Dr. Charles Helmstetter
Florida Institute of Technology
Melbourne, FL
"New Cell Culture Technology"
 
Georgia
Dr. Vincent P. Conticello
Emory University
Atlanta, GA
"Design, Synthesis, and Characterization of Well-Defined,
Biomimetic Polypeptide Networks"
 
Iowa
Professor David Murhammer
University of Iowa
Iowa City, IA
"Monitoring and Control of Rotating Wall Vessels and Application
to the Study of Prostate Cancer"
 
Dr. Tonya L. Peeples
University of Iowa
Iowa City, IA
"Extremophilic Interfacial Systems for Waste Processing in Space"
 
Professor Victor G.J. Rodgers
University of Iowa
Iowa City, IA
"Evaluating Oxidative Stress in Virally Infected Cells in
Simulated Microgravity"
 
Dr. John M. Wiencek
University of Iowa
Iowa City, IA
"Rejuvenation of Spent Media via Supported Emulsion Liquid
Membranes"
 
Indiana
Dr. Christie M. Traycoff
Indiana Cancer Research Institute
Indianapolis, IN
"Self Renewal Replication of Hematopoietic Stem Cells in
Microgravity"
 
Maryland
Dr. Kim D. Collins
University of Maryland Medical School
Baltimore, MD
"Ions and Protein Association; aw and Protein Crystals"
 
Dr. Jocelyne Diruggiero
University of Maryland, Biotechnology Institute
Baltimore, MD
"Microbial Resistance to Solar Radiation: DNA Damage and
Application of Repair Enzymes in Biotechnology"
 
Dr. Henryk Malak
Microcosm, Inc.
Columbia, MD
"Cellular Oxygen and Nutrient Sensing in Microgravity using Time-
resolved Fluorescence Microscopy"
 
Massachusetts
Dr. Lisa E. Freed
Massachusetts Institute of Technology
Cambridge, MA
"Microgravity Tissue Engineering"
 
Michigan
Dr. Laura R. McCabe
Michigan State University
East Lansing, MI
"Microgravity Regulation of Oncogene Expression and Osteoblast
Differentiation"
 
Missouri
Dr. Anil Kulkarni
St. Louis University Health Sciences Center
St. Louis, MO
"Nutritional Immunomodulation in Microgravity: Application of
Ground-based In Vivo and In Vitro Bioreactor Models to Study Role
and Mechanisms of Supplemental Nucleotides"
 
Mississippi
Dr. W. William Wilson
Mississippi State University
Mississippi State, MS
"Novel Approach Regarding Protein Solubility"
 
North Carolina
Dr. Charles W. Carter
University of North Carolina, Chapel Hill
Chapel Hill, NC
"Quantitative, Mulvariate Methods for Pre-Flight Optimization, and
Post-Flight Evaluation of Macromolecular Crystal Growth"
 
Dr. William E. Kraus
Duke University School of Medicine
Durham, NC
"Differentiation and Maintenace of Skeletal and Cardiac Muscle in
Simulated Microgravity"
 
New Hampshire
Professor Ursula Gibson
Dartmouth College
Hanover, NH
"In-situ Optical Waveguides for Promoting and Monitoring Protein
Crystal Growth"
 
New York
Dr. George T. DeTitta
Hauptman-Woodward Medical Research Institute, Inc.
Buffalo, NY
"Macromolecular Crystallization: Physical Principles, Passive
Devices, and Optimal Protocols"
 
Professor Robert E. Thorne
Cornell University
Ithaca, NY
"Impurity Effects in Macromolecular Crystal Growth"
 
Ohio
Professor Joanne M. Belovich
Cleveland State University
Cleveland, OH
"An Accoustically Assisted Bioreactor for Terrestrial and
Microgravity Applications"
 
Dr. Ben Ovryn
NYMA, Incorporated
Cleveland, OH
"In Situ Monitoring of Biological Materials using Low-Coherence
Interferometric Sensors"
 
Dr. Constance A. Schall
University of Toledo
Toledo, OH
"Influence of Impurities on Protein Crystal Growth"
 
Pennsylvania
Dr. Xiao-lun Wu
University of Pittsburgh
Pittsburgh, PA
"Freely Suspended Liquid Flims and their Applications in
Biological Research"
 
Tennessee
Dr. Gerard J. Bunick
University of Tennessee
Oak Ridge, TN
"Reversible Cryogenic Storage of Macromolecular Crystals Grown in
Microgravity"
 
Texas
Dr. Vimlarani Chopra
University of Texas Medical Branch, Galveston
Galveston, TX
"Differentiation of 3-Dimensional Co-cultures of Myofibroblasts,
Preneoplastic Epithelial and Mononuclear Cells"
 
Dr. Gerard L. Cote
Texas A&M University
College Station, TX
"Investigation of Neuronal Physiology in Simulated Microgravity
using Smart Fluorescent Microcarriers and Bulk Near Infrared
Sensors"
 
Dr. Steve R. Gonda
NASA Johnson Space Center
Houston, TX
"A Microgravity-based, Three-dimensional Trangenic Cell Model to
Quantify Genotoxic Effects in Space"
 
Dr. Elizabeth A. Grimm
University of Texas M.D. Anderson Cancer Center
Houston, TX
"Application of Bioreactor Technolgy for a Preclinical Human Model
of Melanoma"
 
Dr. Arun Rajan
Baylor College of Medicine
Houston, TX
"Islet Cell Assembly and Function in a NASA Microgravity
Bioreactor"
 
Dr. Lynne Rutzky
University of Texas Health Science Center, Houston
Houston, TX
"Impact of Microgravity on Immunogenicity Associated with
Biostructural Changes in Pancreatic Islets"
 
Dr. Glenn F. Spaulding
Clear Lake Medical Foundation, Inc.
Houston, TX
"Application of pH, Glucose, and Oxygen Biosensors to NASA
Rotating Culture Vessels"
 
Virginia
Professor Leland W.K. Chung
University of Virginia Health Sciences Center
Charlottesville, VA
"Modeling Prostate Cancer Skeletal Metastasis and Cell Therapy"
 
Professor Michael C. Wiener
University of Virginia Health Sciences Center
Charlottesville, VA
"Membrane Protein Crystallization Screens Based upon Fundamental
Phenomenology of Detergent and Protein-Detergent Solutions"
 
Washington, DC
Dr. Keith B. Ward
Naval Research Laboratory
Washington, DC
"Investigation of the Particle Dynamics in the Vicinity of Crystal
Surfaces: Depletion Zone Dynamics"
 
Wisconsin
Dr. Peter I. Lelkes
University of Wisconsin Medical School
Milwaukee, WI
"PC12 Pheochromocytoma Cells: A Proven Model System for
Optimizing 3-D Cell Culture Biotechnology in Space"
 
 
 
 
 
-end-